Abstract: How to achieve the unified integration of decentralized information resources, the effective invocation of complex model resources, and the efficient sharing and visualization of decision-making spatio-temporal information based on the integrated needs of government decision-making departments such as smart city operation management, construction planning, and emergency command, become the major challenges in the current development process of the urban comprehensive decision-making. Firstly, the key technologies for the urban comprehensive decision-making, such as perception networking and spatio-temporal information access, geospatial model networking and cognition, and decision spatio-temporal information focusing service are proposed, which breaks through the bottlenecks of urban space-time information intelligence analysis, collaborative decision-making and active-focus services. Then, a prototype system of comprehensive decision-making of spatio-temporal information in smart city is implemented. Taking the gas leak response of Taiyuan as an example, the feasibility and applicability of the system for urban comprehensive decision-making are verified. Finally, three main development trends are summarized, that is, urban (group) stereo perception web, urban (group) model web, and urban (group) space-time big data.