Abstract: Spatial relation research has important applications in conflict detection, cartographic generalization, queries and analysis. Refinement and integrated description of spatial relationships to solve practical problems have become an active direction spatial relationship research. This paper analyzes the shortcomings of current integrated methods to express spatial relationships between lines and regions. We analyze and classify simple topological relations between lines and regions and propose the meta-relation concept. Then, the position, orientation and connecting mode of meta-relations are discussed and an integrated representation model of line-region is detailed. Evaluation criteria for the integrated representation model of spatial relations are brought forward and the proposed model is analyzed using these evaluation criteria.