Abstract: Objective Precise orbit determination of medium and high earth orbital satellites mainly depends onground-based tracking systems,which have limitations such as insufficient tracking arc,low accura-cy,and are often unable to support autonomous navigation.The foundation of a GNSS crosslink net-work provides a new resolution for orbit determination of medium and high earth orbital satellites.This paper introduces a new method,used for orbit determination of medium and high earth orbitalsatellites based on GNSS crosslink ranging observations.The visibility,positioning accuracy,andcrosslink budget has been analyzed and the simulative calculation of Autonomous Orbit Determination(AOD)was performed.The results show that with sufficient visible satellite numbers,positioning ac-curacy,and link margins,the AOD of medium-high earth orbital satellites using GNSS crosslink ran-ging observations can achieve a positioning error within 6min radial,2malong and across;the newmethod is feasible and can open new directions in the application of GNSS.