Abstract: Objectives: Population analysis unit is the spatio-temporal object and basic part of geographical analysis in different urban scenes. Aiming at the problem that the current unit expression model pays less attention to the description of specific population analysis features and lacks the correlation method and reference standard of scene and unit feature expression. This paper proposes a population analysis unit expression model considering urban scene change. Methods: First, the model considers the unit 's demand for feature description of population spatio-temporal analysis in two-dimensional space, as well as the dissimilarity of components such as objects and environments of urban scenes, forming a population analysis unit expression model that integrates scene components. Then, based on the content of model expression, the relationship between urban scene and population analysis unit is analyzed. Referring to the geographic scene modeling method, the correlation characteristics and reference standards between scene and population analysis unit are constructed. Results: In order to verify the rationality of the method, this paper takes the epidemic analysis scenario in Wuhan as a case to realize the population analysis unit modeling and attribute feature dynamic update considering the scenario change. The results shows that the model proposed in this paper can correlate urban scene information with population analysis unit characteristics according to standards and help to improve unit description ability. Conclusions: By associating the information and characteristics of urban scene elements, the model in this paper can enhance the expression ability of units and map the information and characteristics of urban scene in a more standard and reasonable way. It can also provide a reference for the geometric construction of the unit and the interpretation of the analysis results.