Abstract: Based on a set up model of the received signal,this paper presents a system of GPS weak signal acquisition,which aimes at the mitigation of the cross-correlation interference.Focused on the two parts of interference detection and the reconstruction of strong signals,the improvement of the sensitivity of the weak signal acquisition,along with some system parameters,are derived from the simulation.The data sections from different channels are adjusted during the weak signal acquisition.Finally,the acquisition results with the real GPS data are presented.