Abstract: Based on integration of multi-agent system and GIS,the theory and methodology of simulating pedestrians flows in crowds' activity center were studied.The general framework and mathematical expressions of the model were put forward.As well,some expressions of moving decision of pedestrian agents and their implemented techniques were explored and designed.A modeling prototype was developed.As an example,a full scattering process of spectator agents in Shanghai stadium was simulated successfully.A successful simulating of a case of emergence when one or more exits emerge accidents will be very useful for managing and treating crowds' safety in a lot of assembling centers.