Abstract: The crustal structure of Xiachayu-Gonghe geophysical profile in eastern Tibetan plateau is simulated with Bouguer anomaly corrected for sediments and lithosphere.The forward simulation shows that the thickness of upper crust in eastern Tibetan plateau is about 20 km,and the density is 2.78×103 kg·m-3.The bottom interface of middle crust changes from 30-40 km,the density of middle crust is 2.89×103 kg·m-3.The materials with low density of 2.78×103 kg·m-3 exist in middle crust,and those with high density of 3.33×103 kg·m-3 exist at the bottom of middle crust between Wenquan and Tanggemu.The density is 3.10×103 kg·m-3 in lower crust.The shallowest depth of Moho interface is about 56 km,and the deepest one is about 74 km,the undulation of interface is large,the deep Moho locates in Xiachayu,Chayu,Nujiang and Wenquan.