Abstract: Objectives: The location method based on Received Signal Strength Indication (RSSI) fingerprint requires building a fingerprint database of the location area in the offline stage. The traditional static fingerprint collection method is time-consuming and labor-intensive to establish and update the fingerprint database, and the location consistency is easily affected by the terminal difference (such as the difference of the received signal caused by the different hardware of the fingerprint collection phone and the location phone), which hinders the large-scale application of this method. Methods: To address these problems, this paper collects RSSI fingerprints during mobile walking and builds a corresponding mobile collection fingerprint database, constructs feature vectors according to the characteristics of mobile collection fingerprints, proposes sparse feature representation of mobile collection fingerprints, and establishes a fingerprint matching indoor location model based on adaptive compressed sensing algorithm. Results: The experimental results show that the fingerprint collection efficiency is improved by 90.83%, the average location error is 1.96 meters, the root mean square error is 2.75 meters, and the location consistency difference error is improved by 32.67% on average. Conclusions: The method proposed in this paper outperforms the existing algorithms in terms of fingerprint collection efficiency, location accuracy and location consistency of different phones.