Abstract: On September 16th, 2021, general secretary Xi Jinping pointed out in his congratulatory letter to the first international summit on BeiDou scale application: At present, the development of global digitalization is accelerating, and spatiotemporal information, location and navigation services have become an important new infrastructure. With the advent of the new infrastructure era, people engaged in surveying and mapping should think about what the country wants, be anxious about what the country is anxious about, and devote themselves to the wave of "the second 100 years" and "new infrastructure". Firstly, this paper expounds the definition of new infrastructure, and analyzes the difference between new infrastructure and traditional infrastructure. Secondly, it discusses the mission of geo-spatial information science in the three systems of new infrastructure, including information infrastructure, integration infrastructure and innovation infrastructure. The authors believed that we have walked through the so called traditional surveying and mapping which mainly serves topographic maps, and developed into the so called ubiquitous surveying and mapping which mainly focuses in the services of geo-spatial information. At present, we should seize the opportunity and expand the new mission of geo-spatial informatics science in the new infrastructure era, provide spatiotemporal data with good integrity, strong reality and high accuracy for the new infrastructure, and realize digital industrialization, industry digitization and intelligence.