Abstract: 21st century is the age of data explosion growth. In the era of big data, it is urgent to enhance the timeliness and intelligence level of the geo-spatial information science.Artificial intelligence is applied to geo-spatial information science, enhancing the perception and cognition ability of geospatial information processing, and realizing the three processes of perception, cognition and action of geo-spatial information science.Through the integration of geo-spatial big data and AI (artificial intelligence), the macro, meso and micro scale of the earth space, earth observation brain(EOB), smart city brain(SCB) and smart phone brain(SPB) are proposed. EOB, SCB and SPB are highly intelligent systems in the geo-spatial information science. The concept model and the key technologies needed to be solved of EOB, SCB and SPB are introduced in detail, and an example is given to illustrate the process of perception, cognition and active in the primary stage of the EOB, SCB and SPB. In future, EOB, SCB and SPB can observe when, where, what object, what change to push these right information to right person at the right time and right place.