Abstract: Calibration of interferometric parameters with block adjustment is a feasible way to reduce the difference between heights derived from multiple interferometric pairs over large areas. To improve the computational efficiency of block adjustment, a new calibration method for interferometric parameters with airborne InSAR data with block adjustment based on Schreiber rule is proposed. The equivalent error equations are obtained based on Schreiber rule to effectively decrease the dimensions of the coefficient matrix in the normal equations, reduce the requirements for computer configuration, and significantly improve computational efficiency. The calibration experiments are done with Chinese dual antenna airborne InSAR data with different methods. There were few differences in the calibrated interferometric parameters, but the average time of block adjustment decreased. The results show that the proposed method is accurate and effective for calibration of interferometric parameters.