Abstract: Objective A Land use zoning model was constructed by spatial clustering as integrated with GIS andCLONALG.The key technology of this algorithm,including coding,antibody-antigen affinity,anti-body diversity,was improved.This model is verified by a case study of land use zoning in Wulie,Changjiang county,Hainan province.The results show that this model can be used for land use zon-ing in a multi-constrained environment.Due to the advantages of global optimization,this stable andreliablemodel can provide a scientific and rational land use planning scheme to support land use plan-ning and land use regulation and management.