Abstract: Objective The purpose of this study is to develop a decision support system for solving land-use alloca-tion optimization problems.After analyzing the characteristics of land-use allocation optimizationproblems,a framework for multi-objective artificial immune system model for land-use allocation opti-mization was proposed.Then,the architecture and a series of standard application programming inter-faces(APIs)for the system are designed to meet the needs of users with different roles.Finally,theland-use allocation optimization problem of Zigui County in Hubei province of China is employed as acase study to evaluate the functionalities of the system and the performance of the optimization mod-els.